Abstract
A specific 5-adenylic acid (5-AMP) deaminase was studied in preparations of hog ciliary process tissue. It was determined that while the activity of this deaminase is enhanced by adenosinetriphosphate (ATP), this activity is not completely blocked in the absence of ATP. Deamination proceeds only at the expense of 5-AMP, but a myokinase-like-active system may be prepared, such that 5-AMP is added to the substrate pool. In this latter case total levels of deamination are generally reflective of added 5-AMP and myokinase-like reaction accumulated 5-AMP. The general acceptance of ciliary process tissue as the site of aqueous humor production leads one to a reasonable conclusion that the very active 5-AMP deaminase studied plays some as yet unexplained role in the dynamics of aqueous secretion. Possibilities concerning the specific role(s) played are discussed. Functional analogy between aqueous humor and cerebrospinal fluid production is again suggested by the fact that an adenine nucleotide deaminase is found also in choroid plexus tissue.
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