Abstract
Atherosclerotic stenosis of the extramural coronary arteries was quantitated for a series of 223 hearts of adults and found to correlate positively with values for stenosis of the intramural coronary arteries of that series. However, minor grades of extramural coronary stenosis may be associated with advanced stenosis of the intramural coronary arteries and myocardial microinfarction, which may explain symptoms of ischemic heart disease in the absence of demonstrable extramural coronary stenosis. Stenosing lesions of extramural and intramural coronary arteries apparently involve the same process, and develop through reorientation, proliferation and migration of pleomorphic smooth muscle cells of the arterial wall, combined with increased formation of mucopolysaccharides, and elastic and collagen fibers. The process corresponds to that by which coronary arterial stenosis appears to develop in swine and other animals.
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Schedule a callMore From: Virchows Archiv. A, Pathology. Pathologische Anatomie
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