Atherogenic lipid phenotype in a general group of subjects.

Abstract

Abstract Context.—The atherogenic lipid phenotype is a major cardiovascular risk factor, but normal values do not exist derived from 1 analysis in a general study group. Objective.—To determine normal values of all of the atherogenic lipid phenotype parameters using subjects from a general study group. Design.—One hundred two general subjects were used to determine their atherogenic lipid phenotype using polyacrylamide gradient gels. Results.—Low-density lipoprotein (LDL) size revealed 24% of subjects express LDL phenotype B, defined as average LDL peak particle size 258 A or less; however, among the Chinese subjects, the expression of the B phenotype was higher at 44% (P = .02). For the total group, mean LDL size was 265 ± 11 A (1 SD); however, histograms were bimodal in both men and women. After excluding subjects expressing LDL phenotype B, because they are at increased cardiovascular risk and thus are not completely healthy, LDL histograms were unimodal and the mean LDL size was 270 ± 7 A. A small, de...