Abstract
AbstractThe asymmetric synthesis of enantiopure pyrrolidines is reported via a streamlined strategy relying on two sequential C−H functionalizations of simple hydrocarbons. The first step is a regio‐ and stereoselective catalytic nitrene C−H insertion. Then, a subsequent diastereoselective cyclization involving a 1,5‐hydrogen atom transfer (HAT) from a N‐centered radical leads to the formation of pyrrolidines that can then be converted to their free NH‐derivatives.
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