Abstract
We propose a method for the synthesis of aspartic and α-methylaspartic acids by alkylation with ethyl bromoacetate of the α-carbon atom of the amino acid moiety in Ni(II) complexes of Schiff bases of glycine with (S)-2-[(N-benzylprolyl)amino]benzophenone and alanine with (S)-2-[(N-benzylprolyl)amino]-benzaldehyde, respectively. Attempts to synthesize α-methylaspartic acid by oxidative cleavage of the C=C bond to a COOH group in the complex of the Schiff base of α-allylalanine with (S)-2-[(N-benzylprolyl)amino]benzophenone were unsuccessful.
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Schedule a callMore From: Bulletin of the Academy of Sciences of the USSR Division of Chemical Science
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