Abstract
Abstract A palladium-catalyzed asymmetric bis(alkoxycarbonylation) reaction of cyclic olefins in the presence of copper(I) triflate was achieved by using a chiral bioxazoline ligand under normal pressure of carbon monoxide and oxygen to give the corresponding optically active cis-dicarboxylates with enantioselectivities up to 94% ee. The carbonylated product was well applied to the synthesis of a biologically active hexahydrobenz[e]isoindole derivative.
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