Abstract
Building on their extensive studies of asymmetric iridium-catalyzed allylic aminations, the authors reported a practical method to synthesize primary allylic amine precursors 3 and 6. The reaction makes use of easily handled amine salts and low catalyst loadings to obtain the products in high ee. Further, a direct enantioselective allylation with ammonia was reported for the first time with a metal catalyst. The reaction yielded the secondary amine 7, which is a useful precursor for the synthesis of C 2-symmetric pyrrolidines.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
