Abstract
Astrocyte specific proteins content in the different parts of the rat and mongolian gerbil brain during ontogenesis
Highlights
During formation and maturation, the brain gradually develops and manifests astroglia
The distribution of glial fibrillary acidic protein (GFAP) in different parts of the brain is uneven and depends on the number of astroglial cells: it is known that the content of astroglial cells in adult rats is maximum in the medulla oblongata and minimum in the cerebral cortex [13]
In the cerebellum and thalamus, total protein contents gradually increased during the developmen
Summary
During formation and maturation, the brain gradually develops and manifests astroglia. Astrocytes are the most common glial cells in the central nervous system (CNS) [1] These glial cell types interact closely with neurons to provide structural [2], metabolic, and trophic [3] support and are actively involved in modulating the excitability of neurons and nerve impulses [4]. Lecular index of neurotoxicity and a marker of nerve tissue damage has been proposed [16, 17] This protein is involved in the molecular mechanisms of neuron-astrocyte interactions [18]. The S100B protein was discovered by Moore [20] and is considered one of the nodal molecular components of complex intracellular systems that ensure the functional homeostasis of brain cells by combining and integrating various calciumdependentmetabolic processes. This study aimed to investigate the redistribution and quantitative indicators of astrocyte-specific proteins, S100B and GFAP, in different parts of the brains of rats and Mongolian gerbils at different stages of ontogenesis
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