Abstract
BackgroundThe trend of association between overweight and high serum total cholesterol (TC) among the elderly is unclear. In addition, there is little evidence of risk of underweight for high TC. Therefore, we examined the trend of association of overweight or underweight with high TC among Japanese elderly people using nationwide population-based data.MethodsData of the National Survey on Circulatory Disorders and National Health and Nutrition Survey for 1980, 1990, 2000, and 2010 were used in the analysis. High TC was defined as 220 mg/dL and above. For participants aged ≥50 years, sex-specific odds ratios (ORs) of overweight or underweight compared with normal body mass index participants for high TC were calculated using a logistic regression model adjusted for age, smoking, drinking, exercise, food, and treatment of hyperlipidemia.ResultsA total of 5,734, 4,673, 5,059, and 2,105 participants enrolled in these surveys in 1980, 1990, 2000, and 2010, respectively. Although overweight was positively and significantly associated with high TC in 1980, the association has gradually weakened since (ORs in 1980 and 2010 were 2.44; 95% confidence interval [CI], 1.83–3.24 and 0.92; 95% CI, 0.66–1.27 among men and 1.43; 95% CI, 1.18–1.72 and 1.08; 95% CI, 0.81–1.44 among women, respectively). While underweight was inversely and significantly associated with high TC in 1980, the association also gradually weakened among women (ORs in 1980 and 2010 were 0.28; 95% CI, 0.12–0.60 and 0.37; 95% CI, 0.10–1.28 among men and 0.39; 95% CI, 0.26–0.57 and 0.96; 95% CI, 0.58–1.57 among women, respectively).ConclusionsThese findings provide evidence that high TC prevention efforts must expand the target to not only overweight but also to normal and underweight people.
Highlights
IntroductionOne-third of the world population is obese or overweight.[1] Over the past three decades, the proportion of overweight has increased from 19.0% to 28.7% among Japanese men.[2] Among Japanese women, the proportions of overweight were 20.1% and 21.3% in 1984 and 2014, respectively.[2] the proportion of overweight is still higher among the elderly than young participants; the proportion of overweight in participants at 20–29 years and 60–69 years of age was 20.9% and 31.2% among men and 10.4% and 24.0% among women, respectively.[2] The aging rate of the population in Japan is the highest in the world
Setting The present study used data from the National Integrated Project for Prospective Observation of Non-communicable Disease And Its Trends in the Aged (NIPPON DATA), which is supported by the Ministry of Health and Welfare of Japan and consists of ongoing cohort studies conducted using the National Survey on Circulatory Disorders (NSCD) and National Health and Nutrition Survey (NHNS) in 1980, 1990, and 2010
A total of 5,734, 4,673, 5,059, and 2,105 participants aged ≥50 years were enrolled in the NSCD and NHNS in 1980, 1990, 2000, and 2010, respectively
Summary
One-third of the world population is obese or overweight.[1] Over the past three decades, the proportion of overweight has increased from 19.0% to 28.7% among Japanese men.[2] Among Japanese women, the proportions of overweight were 20.1% and 21.3% in 1984 and 2014, respectively.[2] the proportion of overweight is still higher among the elderly than young participants; the proportion of overweight in participants at 20–29 years and 60–69 years of age was 20.9% and 31.2% among men and 10.4% and 24.0% among women, respectively.[2] The aging rate of the population in Japan is the highest in the world. We examined the trend of association of overweight or underweight with high TC among Japanese elderly people using nationwide population-based data
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