Abstract
BackgroundBody mass-independent parameters might be more appropriate for assessing cardiometabolic abnormalities than weight-dependent indices in Asians who have relatively high visceral adiposity but low body fat. Dual-energy X-ray absorptiometry (DXA)-measured trunk-to-peripheral fat ratio is one such body mass-independent index. However, there are no reports on relationships between DXA-measured regional fat ratio and cardiometabolic risk factors targeting elderly Asian men.MethodsWe analyzed cross-sectional data of 597 elderly men who participated in the baseline survey of the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study, a community-based single-center prospective cohort study conducted in Japan. Whole-body fat and regional fat were measured with a DXA scanner. Trunk-to-appendicular fat ratio (TAR) was calculated as trunk fat divided by appendicular fat (sum of arm and leg fat), and trunk-to-leg fat ratio (TLR) as trunk fat divided by leg fat.ResultsBoth TAR and TLR in the group of men who used ≥ 1 medication for hypertension, dyslipidemia, or diabetes (“user group”; N = 347) were significantly larger than those who did not use such medication (“non-user group”; N = 250) (P < 0.05). After adjusting for potential confounding factors including whole-body fat, both TAR and TLR were significantly associated with low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride, fasting serum insulin, and the insulin resistance index in the non-user group and non-overweight men in the non-user group (N = 199).ConclusionThe trunk-to-peripheral fat ratio was associated with cardiometabolic risk factors independently of whole-body fat mass. Parameters of the fat ratio may be useful for assessing cardiometabolic risk factors, particularly in underweight to normal-weight populations.
Highlights
Body mass-independent parameters might be more appropriate for assessing cardiometabolic abnormalities than weight-dependent indices in Asians who have relatively high visceral adiposity but low body fat
The present study aimed to investigate the relationship between Dual-energy X-ray absorptiometry (DXA)-measured trunk-to-peripheral fat ratio and cardiometabolic risk factors in community-dwelling elderly Japanese men using baseline data from the second Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study
Trunkto-appendicular fat ratio (TAR) was calculated as trunk fat divided by appendicular fat, and trunk-to-leg fat ratio (TLR) as trunk fat divided by leg fat
Summary
Body mass-independent parameters might be more appropriate for assessing cardiometabolic abnormalities than weight-dependent indices in Asians who have relatively high visceral adiposity but low body fat. Dual-energy X-ray absorptiometry (DXA)-measured trunk-to-peripheral fat ratio is one such body mass-independent index. There are no reports on relationships between DXA-measured regional fat ratio and cardiometabolic risk factors targeting elderly Asian men. Some individuals are not obese or overweight according to standard weight tables, but have metabolic abnormalities that are characteristically associated with obesity [1]. Most MONW individuals have increased abdominal adipose tissue, i.e., a metabolically adverse condition, with a relatively low body mass index (BMI) [4]. Associations between BMI and health risks differ in Asians compared with Europeans. Ethnic differences in visceral adiposity as measured by computed tomography have been reported [4]
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