Abstract
BackgroundDyslexia is a polygenic speech and language disorder characterized by an unexpected difficulty in reading in children and adults despite normal intelligence and schooling. Increasing evidence reveals that different speech and language disorders could share common genetic factors. As previous study reported association of GNPTAB, GNPTG and NAGPA with stuttering, we investigated these genes with dyslexia through association analysis.ResultsThe study was carried out in an unrelated Chinese cohort with 502 dyslexic individuals and 522 healthy controls. In all, 21 Tag SNPs covering GNPTAB, GNPTG and NAGPA were subjected to genotyping. Association analysis was performed on all SNPs. Significant association of rs17031962 in GNPTAB and rs882294 in NAGPA with developmental dyslexia was identified after FDR correction for multiple comparisons.ConclusionOur results revealed that the stuttering risk genes GNPTAB and NAGPA might also associate with developmental dyslexia in the Chinese population.Electronic supplementary materialThe online version of this article (doi:10.1186/s12863-015-0172-5) contains supplementary material, which is available to authorized users.
Highlights
Dyslexia is a polygenic speech and language disorder characterized by an unexpected difficulty in reading in children and adults despite normal intelligence and schooling
Speech and language disorders can be classified into numerous categories, including stuttering, speech sound disorder (SSD), verbal dyspraxia, specific language impairment (SLI) and developmental dyslexia (DD) [1]
Single marker analysis In the present study, we performed genotyping on Tag SNPs of three candidate genes for stuttering, Nacetylglucosamine-1-phosphate transferase gene (GNPTAB), GNPTG and Nacetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (NAGPA)
Summary
Dyslexia is a polygenic speech and language disorder characterized by an unexpected difficulty in reading in children and adults despite normal intelligence and schooling. As previous study reported association of GNPTAB, GNPTG and NAGPA with stuttering, we investigated these genes with dyslexia through association analysis. Known as reading disability (RD), is characterized by difficulties in reading and spelling despite of normal intelligence and adequate education background without any neurological impairments [2,3]. Though language disorders such as dyslexia are quite different concept from speech disorders, in many cases, it is difficult to discriminate a language disorder from a speech disorder in a specific individual [4]. Based on the above evidence, we performed association analysis on these genes with dyslexia in a large unrelated Chinese cohort
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