Association study of a new schizophrenia susceptibility locus of 10q24.32–33 in a Han Chinese population

Abstract

Recently, a new schizophrenia susceptibility locus 10q24.32–q24.33, containing two single-nucleotide polymorphisms (SNPs: rs7914558 and rs11191580), was identified in a genome-wide association study. To examine if this locus is associated with schizophrenia in the Han Chinese population, we analyzed six SNPs, including two SNPs within the region of interest. The sample consisted of 1430 schizophrenia cases and 1570 controls from genetically independent members of the Han population. Single-SNP association, haplotype association and sex-specific association analyses were performed. Three SNPs, rs7914558 (p=1.41×10−4; OR=1.11; 95% CI 1.05–1.17), rs12220375 (p=1.18×10−4; OR=1.06; 95% CI 1.03–1.09) and rs11191580 (p=3.03×10−4; OR=1.05; 95% CI 1.02–1.10), mapped to the locus and were significantly associated in our sample set. Further genotype and haplotype association analyses suggested a similar pattern. Similar to results from European populations, our results provide further evidence that this region associated with schizophrenia in Han Chinese. Results also confirm previous reports suggesting that 10q24.32–q24.33 offers an intriguing new insight into the pathogenesis of schizophrenia and may play an important role in its etiology.