Abstract
Background: Animal models suggest that exposure to BPA might increase allergic inflammation. Little is known about if BPA may affect the development of allergic diseases. We want to address the effect of BPA exposure on the development of sensitization and asthma. Methods: A total of 453 children from the Childhood Environment and Allergic diseases Study (CEAS) cohort with urine samples were recruited. Urine BPA glucoronide (BPAG) levels at age 3 and 6, as an indicator of exposure, were measured by ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS). At age 3 and 6, information on serum IgE levels and the development of asthma was collected. The association between BPA levels at different stages and IgE levels and asthma was evaluated by multivariate linear regression and logistic regression. Results: The geometric mean levels of urine BPAG at age 3 were higher than those at age 6 (5.71 vs 4.74µg/g creatinine). BPAG levels at age 3 positively correlated with serum IgE levels (per ln-unit: β=62.80 KU/l, p=0.02). Interestingly, analyses stratified by gender revealed that BPAG levels positively correlated with IgE only in girls (per ln-unit: β=135.52 KU/l, p
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