Abstract
We investigated whether expression of non-selective cation channels of the transient receptor potential canonical (TRPC) channel family are associated with proinflammatory cytokines in monocytes. Using quantitative RT-PCR we studied the expression of TRPC3, interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) in monocytes from 15 patients with essential hypertension and 16 age- and sex-matched normotensive control subjects. We observed an approximately 8-fold increase of TRPC3 transcripts in monocytes from patients with essential hypertension compared to normotensive control subjects ( p < 0.05). We found an approximately 3-fold increase of IL-1β, and an approximately 9-fold increase of TNF-α in patients with essential hypertension compared to normotensive control subjects (each p < 0.05). We observed a significant correlation between TRPC3 transcripts with systolic blood pressure, expression of IL-1β, and TNF-α. Using quantitative RT-PCR we observed an association of TRPC3 transcripts and proinflammatory cytokines in monocytes.
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