Abstract
ObjectiveRegulation of single nucleotide polymorphisms (SNP) in micro-RNA (miRNA) on the host cells may be one of the most important factors influencing the occurrence of cervical cancer based on the prevalence of HPV infection and the development of cervical cancer. In order to explore the contribution of miRNA polymorphism to the occurrence and development of cervical cancer, we conducted an analytical study.MethodsWe selected the polymorphisms of three widely studied miRNAs (miRNA-146a rs2910164, miRNA-499 rs3746444, and miRNA-196a2 rs11614913). Then, we conducted a meta-analysis (for the first time) to investigate their susceptibility to cervical cancer. Case control studies on the correlation between these three miRNAs and cervical cancer susceptibility were investigated by searching on from Pubmed, The Cochrane Library, Embase, CBM, CNKI, Wanfang database, and VIP database. Basic characteristics were recorded and meta-analysis of the case studies was performed using the STATA 15.1 software.ResultsThe miRNA-146a rs2910164 mutation significantly reduced the risk of cervical cancer in both recessive model (OR = 0.804, 95% CI = 0.652-0.992, P = 0.042; CC vs. CG+GG) and allelic model (OR = 0.845, 95% CI = 0.721-0.991, P = 0.038; C vs. G). There was no significant correlation between miRNA-499 rs3746444 and the risk of cervical cancer. The miRNA-196a2 rs11614913 mutation was significantly associated with a reduced risk of cervical cancer in homozygous model (OR = 0.641, 95% CI = 0.447-0.919, P = 0.016; TT vs. CC), dominant model (OR = 0.795, 95% CI = 0.636-0.994, P = 0.045; CT+TT vs. CC), recessive model (OR = 0.698, 95% CI = 0.532-0.917, P = 0.01; TT vs. CC+CT), and allelic models (OR = 0.783, 95% CI = 0.643-0.954, P = 0.015, T vs. C).ConclusionIn summary, this meta-analysis shows that the mutant genotypes of miRNA-146a rs2910164 and miRNA-196a2 rs11614913 are associated with a reduced risk of cervical cancer. Therefore, they may be two gene regulatory points for the prevention of cervical cancer.Systematic review registrationPROSPERO registration number CRD42021270079.
Highlights
Cervical cancer is the second most common malignancy in women, whose incidence is second only to breast cancer [1]
Five studies related to the correlation between miRNA146a rs2910164 and cervical cancer; three related to the correlation between miRNA-499 rs3746444 and cervical cancer; and six related to the correlation between miRNA-196a2 rs11614913 and cervical cancer
Relationship between miRNA‐196a2 rs11614913 and cervical cancer The combined analysis showed that mutant TT was significantly associated with a lower risk of cervical cancer compared to the wild homozygous CC (OR = 0.641, 95% Confidence interval (CI) = 0.447-0.919, P = 0.016; TT vs. CC)
Summary
Cervical cancer is the second most common malignancy in women, whose incidence is second only to breast cancer [1]. About 500,000 new cases of cervical cancer occur globally each year, accounting for 5% of all new cancer cases. More than 260,000 women die of cervical cancer [2], accounting for 7.5% of all female cancer. Xu et al World Journal of Surgical Oncology (2021) 19:346 deaths. Cervical cancer is an important disease endangering women’s health and life [3, 4]. Focusing on women’s health is an important step in human reproduction and development. In the face of cervical cancer, we still focus on prevention. The factors affecting the occurrence and development of cervical cancer are worthy of our research and discussion
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
