Abstract
Epstein-Barr virus (EBV) may be a cofactor in the development of different malignancies, including several types of carcinomas. We demonstrated the presence of EBV in human breast cancers. We detected the EBV genome by PCR in 51% of the tumor biopsies. In 90% of the cases studied, the virus was not detected in healthy tissue. The presence of the EBV genome in breast tumors was confirmed by Southern-blot analysis. The EBV latent protein EBNA-1 was observed in a fraction (5-30%) of tumor epithelial cells. Expression of the EBV genes BNLF1 and BARF0 will be reported. A statistical relationship was established between the presence of EBV and several poor prognostic factors. EBV may be a cofactor in the development of a subset of breast cancers. Latently EBV infected breast undifferentiated human epithelial cell line, MDA-MB-231, was obtained and injected into nude mice. Tumors were obtained in which EBV persists. The persistence of EBV in nude mice tumors, in the absence of any selection, suggests that mammary epithelial cells could be a natural host for EBV. These models will be used for the elaboration of specific therapeutic targets. Normal breast mammary epithelial cells are now being infected by EBV in order to investigate the oncogenic potential of EBV in those epithelial cells.
Highlights
Lymph node biopsy is important as a prognostic factor, and influences therapy
In this study we determined the in vivo cell kinetics along the spectrum of apparently normal epithelium, hyperplasia, preinvasive lesions and invasive carcinoma, in breast tissues affected by fibrocystic changes in which preinvasive and/or invasive lesions developed, as a model of breast carcinogenesis
This study was undertaken to determine the effect of wound healing drainages and postsurgical sera obtained from breast carcinoma (BC) patients on proliferation of dormant BC cells and to assess the role of HER2 oncoprotein in this proliferation
Summary
Lymph node biopsy is important as a prognostic factor, and influences therapy. In the transition from normal epithelium to hyperplasia and from preinvasive lesions to invasive carcinoma, the net growth of epithelial cells results from a growth imbalance in favour of proliferation. The objective of this study was to assess the efficacy of hyperbaric oxygen therapy in symptomatic patients after breast cancer treatment. Conclusion: Hyperbaric oxygen therapy should be considered as a treatment option for patients with persisting symptomatology following breast-conserving therapy. We hypothesized that COX-2 expression was associated with that of vascular endothelial growth factor (VEGF) and proliferating cell nuclear antigen (PCNA) in human breast cancer. Conclusion: COX-2 expression is significantly associated with increased cellular proliferation and angiogenesis in invasive breast cancer. Recent studies have demonstrated that the sentinel node biopsy (SNB) is a reliable and minimally invasive method for determining the axillary node status in patients with breast cancer. Conclusion: Overexpression of episialin strongly inhibits fat secretion, and critically affects timing of involution of the lactating mammary gland
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