Association of single nucleotide polymorphisms (SNPs) in inflammatory pathways with breast cancer (BC) risk: A multi-ethnic scoping review.

Abstract

1617 Background: Breast cancer is the most prevalent cancer affecting women of every ethnic group in the United States. This is a scoping review assessing SNPs in inflammatory pathways posited to modify BC risk by ethnicity. Methods: We followed PRISMA guidelines for scoping reviews. PubMed, Medline, and OVID databases were interrogated for publications between 1/2000-12/2023 using search terms “breast cancer” AND [BMI OR “body mass index” OR elevated BMI OR obesity] AND [SNP OR “single nucleotide polymorphism” OR polymorphism OR mutation] AND [inflammation OR cytokines OR IL-1 OR IL-2 OR IL-4 OR IL-6 OR IL-8 OR IL-10 OR IL-12 OR TNF-A or TGFB OR CRP] AND [Asian, Black or Hispanic]. A single reviewer assessed 72 unique publications and determined that 42 met inclusion criteria. Two reviewers extracted the following data: demographics, SNP, number of cases and controls by ethnicity. Disagreements were resolved by consensus with a third reviewer. Results: Data were extractable from 42 studies, all case controls. In analyses stratified by ethnicity, we detected effects of SNPs on BC risk (Table). IL-1β rs1143634 and IL-10 (1082 A/G) had a significantly increased BC risk in Asian populations but insignificant in white populations. There were minimal publications for Black and Hispanic populations. Conclusions: The association of inflammatory SNPs and BC risk is complex and can be both protective and predisposing to BC, with ethnicity modifying SNP risk. Future research can be directed at assessment of SNPs and BC risk in diverse populations. [Table: see text]