Association of serumγ-glutamyl transpeptidase level with kidney function in essential hypertension patients

Abstract

Objective To analyze the association of serumγ-glutamyl transpeptidase (GGT) level with kidney function in essential hypertension patients. Methods 500 patients with essential hypertension were selected.They were divided into high glomerular filtration rate (GFR) group, normal renal function group, mild renal function decline group, and moderate or severe renal function decline group based on GFR.The fasting blood glucose, serum lipid, routine laboratory tests, hepatic and renal function were detected by routine methods.The one way ANOVA test was used to show differences among groups, and the relationship of serum GGT with GFR was assessed by using the Pearson correlation coefficient and multiple linear regressions. Results There were 500 hypertension patients[(56.03±7.38)years old, 240 males and 260 females] enrolled in this study.Among them, 43(23/20) cases were in the high GFR group, 161(82/79) cases were in the normal renal function group, 219(105/114) cases were in the mild renal function decline group, and 77(30/47) cases were in the moderate or severe renal function decline group.The sex, blood pressure, heart rate, body mass index, fasting blood glucose, blood lipid level had no statistically significant differences among the groups (all P>0.05), but the age, aspartate transaminase(AST), alanine transaminase(ALT) and GGT had statistically significant differences among the groups (all P<0.05). Pearson correlation analysis showed: age(r=0.278, P=0.002) was negatively associated with GFR, while AST(r=0.159, P=0.003), ALT(r=0.352, P<0.001) and GGT(r=0.237, P<0.001) were positively correlated with GFR.Multiple linear regression analysis showed that the serum GGT (β=0.146, 95%CI 0.099, 0.282, P<0.001) was also positively correlated with GFR. Conclusion Our study demonstrated that the level of GGT was positively correlated with GFR in essential hypertension patients, and monitoring the changes of serum GGT may have significant effect on kidney function. Key words: Hypertension; Serumγ-glutamyl transpeptidase; Glomerular filtration rate