Abstract
Objectives The purpose of this study was to explore the association of serum lipocalin-2 concentrations with psoriasis and psoriatic arthritis (PsA). Methods A systematic search of studies on the association of serum lipocalin-2 concentrations with psoriasis/PsA was conducted in PubMed, Web of Science, Elsevier ScienceDirect, and Cochrane Library. Eventually, 8 eligible studies were included. The strength of association between serum lipocalin-2 concentrations and psoriasis/PsA was assessed by pooled standard mean difference (SMD) with its 95% confidence intervals (CIs). Results A total of 8 case-control studies, consisting of 349 psoriasis/PsA patients and 258 controls, were included in the meta-analysis. This meta-analysis showed significant association between serum lipocalin-2 concentrations and psoriasis/PsA in overall population (SMD: 0.757, 95%CI = 0.588‐0.926, and PH = 0.114; PH is the P value for the heterogeneity test). Similar results were found in subgroup analysis by ethnicity. Conclusions Serum lipocalin-2 concentrations are higher in psoriasis/PsA patients than controls. However, more large-scale studies are warranted to explore the association between serum lipocalin-2 and the pathogenetic mechanisms of psoriasis/PsA.
Highlights
Psoriasis is a common, chronic, immune-mediated, inflammatory skin disease characterized by the formation of welldemarcated, erythematous plaques with silvery scales [1,2,3]
Our meta-analysis included eight case-control studies which were about the association between serum lipocalin-2 levels and psoriasis/Psoriatic arthritis (PsA)
Our meta-analysis indicated that serum lipocalin-2 levels were significantly higher in psoriasis/PsA patients than in controls (SMD: 0.757, 95%confidence intervals (CIs) = 0 588‐ 0 926, and PH = 0 114; PH is the P value for the heterogeneity test)
Summary
Chronic, immune-mediated, inflammatory skin disease characterized by the formation of welldemarcated, erythematous plaques with silvery scales [1,2,3]. The etiology of psoriasis is very complex, which is affected by both genetic and environmental factors. Psoriasis has been recognized as an independent risk factor for myocardial infarction, which may cause serious negative impact on the quality of life [7]. Psoriatic arthritis (PsA) is a chronic, inflammatory, and debilitating arthritis associated with psoriasis [8]. The etiology of psoriasis and PsA is unknown; some studies have shown that adipokines and cytokines may play an important role in its pathogenetic mechanisms [9, 10]
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