Abstract
BackgroundSeveral studies have identified a negative association between serum glycine (Gly) levels and metabolic syndrome (MetS). However, this association has not been fully established in the elderly.MethodsA total of 472 Chinese individuals (272 males and 200 females, 70.1 ± 6.6 years old) participated in a population-based, cross-sectional survey in Beijing Hospital. The MetS and its components were defined based on the 2006 International Diabetes Federation (IDF) standard for Asians. Serum Gly concentration was determined using isotope dilution liquid chromatography tandem mass spectrometry.ResultThe proportion of patients with MetS decreased gradually with increasing Gly levels (p for trend < 0.001), and serum Gly concentrations declined gradually with increasing numbers of MetS components (p = 0.03 for trend). After adjusting for age and gender, lower Gly levels were significantly associated with MetS and central obesity, with OR (95% CI) of 0.40 (0.25–0.65) and 0.46 (0.28–0.74). The stratified analysis conducted according to age showed that the OR between serum Gly levels and MetS was greater in those older than 65 (OR = 0.66; 95% CI, 0.51–0.86) than in those younger than 65 (OR = 0.89; 95% CI, 0.54–1.46). In the stratified analysis, using other age cut-off points, the results consistently showed that the association between serum Gly levels and MetS was more remarkable in the older groups.ConclusionsGly levels are associated with cardiometabolic characteristics and MetS in the elderly, and the association is more pronounced in very old people than in younger old people.
Highlights
In recent years, the improvements in living standards, economic development, and lifestyle changes have led to a longer life expectancy for older people, and the global elderly population has continued to increase
Gly levels are associated with cardiometabolic characteristics and metabolic syndrome (MetS) in the elderly, and the association is more pronounced in very old people than in younger old people
We proposed to use a cross-sectional study of 472 Chinese subjects, of whom about 80% are older than 65 years old, to investigate the association between serum Gly levels and MetS in the elderly and whether this association in the elderly is different from relatively young adults
Summary
Study population The design of and recruitment for the population-based cross-sectional study has been described in detail elsewhere [17]. The serum samples were tested for fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein (apo) AI and B, and high-sensitive C-reactive protein (CRP), using assay kits from Sekisui Medical Technologies (Osaka, Japan) on a Hitachi 7180 chemistry analyzer. All correlation coefficients were calculated after adjustment for age and gender Abbreviations: Gly glycine, BMI body mass index, WC waist circumference, SBP systolic blood pressure, DBP diastolic blood pressure, FBG fasting blood glucose, TC total cholesterol, TG triglyceride, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, CRP high-sensitivity Creactive protein. Serum Gly levels were depicted according to the number of MetS components, using a linear regression model. The performance of Gly measurements for classifying MetS status was assessed by logistic regression and receiver operating characteristic analysis. SPSS 21.0 software (SPSS Inc.) was used for statistical analysis of the data, and PASS 15.0 software was used for calculating the statistical power
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