Abstract

This study aims to investigate the correlation of PvuII (rs2234693) and XbaI (rs9340799) polymorphisms in estrogen receptor alpha (ESR1) gene with Chronic Hepatitis B Virus Infection, and provide new insight and scientific basis for controlling chronic infection of hepatitis B virus (HBV). We selected 107 healthy subjects as the control group and 107 patients with chronic hepatitis B (CHB) as the treated group. The molecular diagnosis methods of PCR-HRM based on the high-resolution melting curve (HRM) technique were employed to determine the gene polymorphisms of two SNPs: rs2234693 (T > C) and rs9340799 (A > G). The correlations between these two single nucleotide polymorphisms (SNP) sites and HBV chronic were further verified by gel electrophoresis and following sequencing. It was found that the genotype frequencies of rs2234693 (T > C) site were significantly different between CHB cases and the controls (P G) of estrogen-receptor gene ESR1 may be the genetic susceptibility gene of HBV infection. The GG genotype is associated with chronic infection of HBV.

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