Association of Parkinson disease to PARK16 in a Chilean sample

Abstract

Parkinson’s disease (PD) is one of the most common neurodegenerative disorders worldwide with a prevalence of ∼3% in persons over the age of 65 years. Genetic causes of PD have been identified using both linkage and association approaches [ [1] Klein C. Schlossmacher M.G. Parkinson disease, 10 years after its genetic revolution: multiple clues to a complex disorder. Neurology. 2007; 69: 2093-2104 Crossref PubMed Scopus (174) Google Scholar ]. Recently, two genome-wide association (GWA) studies in PD using Asian and Caucasian patients and controls of Japanese and European origin have identified common susceptibility variants reaching genome-wide significance [ 2 Simon-Sanchez J. Schulte C. Bras J.M. Sharma M. Gibbs J.R. Berg D. et al. Genome-wide association study reveals genetic risk underlying Parkinson’s disease. Nat Genet. 2009; 41: 1308-1312 Crossref PubMed Scopus (1445) Google Scholar , 3 Satake W. Nakabayashi Y. Mizuta I. Hirota Y. Ito C. Kubo M. et al. Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson’s disease. Nat Genet. 2009; 41: 1303-1307 Crossref PubMed Scopus (1027) Google Scholar ]. Among several other loci, the Japanese study described variants with p-values between 10−7 and 10−12 which are located at a new susceptibility locus on chromosome 1q32 called PARK16 [ [3] Satake W. Nakabayashi Y. Mizuta I. Hirota Y. Ito C. Kubo M. et al. Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson’s disease. Nat Genet. 2009; 41: 1303-1307 Crossref PubMed Scopus (1027) Google Scholar ]. Analysis of PARK16 in the European sample also showed significant association with PD for rs823128 at PARK16 (p-value of 7 × 10−8) [ [2] Simon-Sanchez J. Schulte C. Bras J.M. Sharma M. Gibbs J.R. Berg D. et al. Genome-wide association study reveals genetic risk underlying Parkinson’s disease. Nat Genet. 2009; 41: 1308-1312 Crossref PubMed Scopus (1445) Google Scholar ].