Abstract
Objective We aimed to assess the association of the oxidative balance score (OBS) with metabolic syndrome (MetS) in adults. Design A population-based cross-sectional study Setting. Health centers from five districts in Tehran, Iran. Methods We recruited 847 participants with an age range of 18-65 years. Dietary intake was assessed by a semiquantitative food frequency questionnaire with 168 items. The OBS was calculated by using the following 13 dietary and nondietary anti- and prooxidant components: dietary antioxidants (selenium, fiber, β-carotene, vitamin D, vitamin C, vitamin E, and folate), dietary prooxidants (iron and saturated and polyunsaturated fatty acids), and nondietary anti- (physical activity) and prooxidants (smoking and obesity). The odds ratio (OR) and 95% confidence interval (CI) of the MetS and its components across tertiles of the OBS were calculated by logistic regression analysis, controlling for age, sex, energy intake, occupation, and educational level. Results The range of OBS was between 16 and 39. Being in the top versus the bottom tertile of the OBS was not associated with the MetS (OR = 0.71, 95% CI 0.48-1.03; P = 0.07), after controlling for potential confounders. Higher OBS score was associated with a lower likelihood of abdominal obesity (OR: 0.55, 95% CI: 0.38-0.81; P = 0.003) and increased diastolic blood pressure (OR: 0.64, 95% CI: 0.41-0.99; P = 0.04). Higher OBS was not associated with other components of the MetS. Conclusion Overall, the present study showed that there was no significant relationship between OBS and MetS in Tehranian adults.
Highlights
The metabolic syndrome (MetS) is a collection of several metabolic disorders including abdominal obesity, dyslipidemia, hypertension, hyperglycemia, inflammation, high body mass index (BMI), and insulin resistance [1]
Due to the fact that cluster sampling is two-stage and the response of individuals in each health center may be correlated, the number of samples is multiplied by the effect factor of the cluster design selected as 1.5, and the total number of samples 819 is obtained, which we consider as 850, because this data is taken from the previous design and the effect of dietary pattern on obesity is more sensitive than its effect on cardiometabolic and inflammatory biomarkers; in the present study, the sample size of 850 is considered
There were no significant differences in gender, age, smoking status, and dietary intake of selenium, polyunsaturated fatty acid (PUFA), and Saturated fatty acid Waist circumference (WC) (SFA) across tertiles of the oxidative balance score (OBS)
Summary
The metabolic syndrome (MetS) is a collection of several metabolic disorders including abdominal obesity, dyslipidemia, hypertension, hyperglycemia, inflammation, high body mass index (BMI), and insulin resistance [1]. Obesity seems to exacerbate the body’s oxidant/antioxidant balance in favour of free radicals and oxidative stress [9,10,11]. The ability of the antioxidant defence system decreases to stop the activities of free radicals, so multifactorial metabolic disorders such as hypertension will appear [12]. There is evidence that higher dietary antioxidant intake can mitigate levels of oxidative stress and metabolic disorders, namely, diabetes and Oxidative Medicine and Cellular Longevity inflammation [14, 15]. In addition to anti- and prooxidant dietary components, other lifestyle-related behaviours such as cigarette smoking [17], physical activity [18], and adiposity [19] can affect levels of oxidative stress in the body. Several studies have investigated the association between OBS and various chronic diseases like different cancer types and cardiovascular diseases and inflammation [13, 22,23,24]
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