Abstract
The study established the association of nutritional status with drug sensitive and drug resistant outcomes among pulmonary tuberculosis (TB) patients. A hospital based prospective follow-up cohort study design. Two urban Directly Observed Treatment Short-course (DOTS) centers in Lucknow District of Uttar Pradesh, India. The newly diagnosed Acid-fast Bacilli (AFB) positive cases between the age group of 12 to 65 years were enrolled. The drug-susceptibility outcomes were assessed by mycobacterial culture and drugsusceptibility test. The assessment of nutritional status was performed by Body Mass Index (BMI), Mid-upperarm circumference (MUAC), 24-hour dietary recall method and measurement of serum concentration of retinolbinding protein (RBP) and zinc. A total of 185 newly diagnosed patients were recruited. Out of these, 14 patients were lost to follow up after treatment. The mean (±SD) age of the remaining 171 patients was 29 (±12) years. In the culture of 171 patients, 156 (91.2%) isolates were culture positive and subjected to drugsusceptibility test. Of these, 129 (82.6%) isolates were sensitive to all the drugs and 27 (17.3%) isolates were resistant to any drug. A significant difference was observed in serum RBP (p<0.0001) and zinc (p=0.005) at six month in drug sensitive and resistant patients. Among all the nutritional status parameters serum zinc (p=0.01) was significantly associated with drug resistant patients. Inadequate level of serum zinc was probably associated with drug resistance among new pulmonary TB patients.
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