Association of novel antihyperglycemic drugsversusmetformin with COPD exacerbations

Abstract

BackgroundDipeptidyl peptidase-4 inhibitors (DPP-4 Is), glucagon-like peptidase 1 receptor agonists (GLP-1 RAs), and sodium glucose co-transporter-2 inhibitors (SGLT-2 Is) may contribute to better control of chronic obstructive pulmonary disease (COPD) due to their anti-inflammatory effects, like those observed with metformin. We aimed to investigate the association of these novel antihyperglycemic drugsversusmetformin with fewer COPD exacerbations in patients with type 2 diabetes (T2DM) comorbid with COPD.MethodsUsing the national administrative database covering 99% of the medical facilities in Japan, we constructed three active comparators new-user cohorts comprising 36 317 patients with T2DM and COPD who initiated treatment with the novel antihyperglycemic drugs and metformin between 2014 and 2022. Patients’ backgrounds were balanced using overlap propensity score weighting. We calculated the hazard ratios (HRs) and their 95% confidence intervals (CIs) for the initial occurrence of COPD exacerbation requiring systemic corticosteroids using a weighted Cox proportional hazards model.ResultsDPP-4 Is were associated with a higher incidence of exacerbations requiring systemic corticosteroids (22.4versus20.4 per 100 person-years; HR [95% CI] 1.16 [1.07–1.25]) compared with metformin. In contrast, the incidence of such exacerbations in the GLP-1 RAs (30.1versus24.4 per 100 person-years; HR [95% CI] 1.07 [0.87–1.32]) and SGLT-2 Is (20.7versus21.8 per 100 person-years; 1.00 [0.94–1.06]) groups were comparable with that in the metformin group.ConclusionsWhile DPP-4 Is were associated with poorer control of COPD compared with metformin, GLP-1 RAs and SGLT-2 Is offered COPD control comparable to that of metformin.