Abstract
Myostatin (MSTN) also known as GDF8 is a negative regulation factor which determines the maximal amount of body mass typical for every species. MSTN is considered as an important candidate gene for meat production. Fontanesi et al. (2008) detected a single nucleotide polymorphism (C-T transition) at position 34 of intron 2 of myostatin gene. If there is a mutation in MSTN gene, its negative regulation function is disrupted leading to double muscle phenotype. The rabbit MSTN gene sequence comprises three exons and two introns as observed in other species. A total of 60 DNA samples of New Zealand White, Soviet Chinchilla and crossbred rabbits were subjected to PCR-based RFLP. An 80 bp fragment of MSTN gene was amplified using PCR and digested with Alu 1 enzyme and polymorphism was detected in the population studied, revealing three genotypes, viz CC, CT and TT. In the present study, CT genotypes were associated with higher body weight but the difference in body weight among different genetic groups was not statistically significant.KeywordsmyostatinpolymorphismMSTN
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