Abstract
Background: There is a deep association between mineral & bone disorders in chronic kidney disease. High phosphate levels in CKD-MBD have been associated with increased all-cause mortality & cardiovascular morbidity & mortality. This study aims to find association of mineral levels with CKD-MBD. Objective is to get data of serum calcium & phosphorus levels in known CKD-MBD patients & evaluate their association with CKD-MBD. Methodology: This is a retrospective analytical study carried out at Dhiraj Hospital, Piparia, Vadodara. Total 71 consented indoor patients were enrolled in study out of 317 requested for consent in provided time period of 6 months, 45 (63.3%) patients with known CKD-MBD & 26 (36.6%) without CKD-MBD were taken as control group. Various laboratory parameters were evaluated & compared. Results: Out of 50 male & 21 female participants total 36 (80%) were found to have low calcium levels & 39 (86.67%) were found to have high phosphorus levels among known CKD-MBD patients which were classified according to eGFR. Conclusion: Low calcium & high phosphorus levels are associated in patients with CKD-MBD. There should be multi-disciplinary approach towards maintenance of mineral levels in patients to meet the K/DOQI guidelines.
Highlights
A CKD-MBD is emerging as one of the major public health problems across the world & its incidence is rising day by day.[1]
Taking cut off values for low calcium as 8.8mg/dl, high phosphorus as 5.6mg/dl & high creatinine as 1.4mg/dl; we found that 42(59.2%), 42(59.2%) & 57(80.3%) were having low calcium level, high phosphorus level & high creatinine levels respectively
Diabetes affected the association of serum phosphorus with mortality in patients with End-stage Renal Disease (ESRD) in the study by Block et al 11, & serum phosphorus was not associated with mortality in a study that was performed in patients who had CKD-MBD & were not yet on dialysis, who almost exclusively did not have diabetes
Summary
A CKD-MBD is emerging as one of the major public health problems across the world & its incidence is rising day by day.[1]. There is a deep association between mineral & bone disorders in chronic kidney disease. This study aims to find association of mineral levels with CKD-MBD. Objective is to get data of serum calcium & phosphorus levels in known CKD-MBD patients & evaluate their association with CKD-MBD. Results: Out of 50 male & 21 female participants total 36 (80%) were found to have low calcium levels & 39 (86.67%) were found to have high phosphorus levels among known CKD-MBD patients which were classified according to eGFR. Conclusion: Low calcium & high phosphorus levels are associated in patients with CKD-MBD.
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