Abstract
Motivated by linkage data and the hypothesis that angiogenesis plays a functional role in rheumatoid arthritis (RA), Jacq and colleagues present a family-based, multi-stage, candidate gene association study in French and European Caucasians in a paper on the association of the ITGAV rs3738919-C variant allele with RA (C-containing genotypes: odds ratio 1.94, confidence interval 1.3 to 2.9, P = 0.002). Support comes from a recent genome-wide study, which on its own would have missed identifying the association. Further research into the associating variant will require detailed haplotype analysis, verification in further studies, and research involving intermediate phenotypes or direct functional experiments. This new RA risk factor supports the role of angiogenesis in the disease.
Highlights
ITGAV was selected as a candidate gene for rheumatoid arthritis (RA) for two reasons
Motivated by linkage data and the hypothesis that angiogenesis plays a functional role in rheumatoid arthritis (RA), Jacq and colleagues present a family-based, multi-stage, candidate gene association study in French and European Caucasians in a paper on the association of the ITGAV rs3738919-C variant allele with RA (C-containing genotypes: odds ratio 1.94, confidence interval 1.3 to 2.9, P = 0.002)
Jacq and colleagues [1] have presented a candidate gene association study in French and European Caucasian populations, showing evidence that the rs3738919-C variant of the gene ITGAV may be associated with rheumatoid arthritis (RA), with an overall odds ratio (OR) for C-containing genotypes of 1.94 and a 95% confidence interval (CI) of 1.3 to 2.9 (P = 0.002)
Summary
ITGAV was selected as a candidate gene for RA for two reasons. First, it is localized 194 centimorgans from the ptelomere of chromosome 2, within a region stretching from 193 to 202 centimorgans that has been implicated by an RA genome scan [2]. Motivated by linkage data and the hypothesis that angiogenesis plays a functional role in rheumatoid arthritis (RA), Jacq and colleagues present a family-based, multi-stage, candidate gene association study in French and European Caucasians in a paper on the association of the ITGAV rs3738919-C variant allele with RA (C-containing genotypes: odds ratio 1.94, confidence interval 1.3 to 2.9, P = 0.002). Support comes from a recent genome-wide study, which on its own would have missed identifying the association.
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