Abstract
Introduction: Diabetes mellitus (DM) is common metabolic disorder leading to various complications including micro-vascular complication. Diabetes and thyroid dysfunction can result in abnormalities of one another, as both are strongly implicated in cellular metabolism. Aim of study was to establish any association between hypothyroidism and micro-vascular complications in patients of type 2 DM.
 Material and Methods: This Hospital based Cross sectional analytical Study was included 80 Euthyroid and 80 hypothyroid patients of type 2 DM. These patients were subjected to fundus examination (for retinopathy), urine for spot albumin and creatinine ratio and routine microscopy (for nephropathy), clinical examination and NCV (for neuropathy).
 Results: Age of patients ranged from 30 – 80 years. Most patients had duration of Diabetes > 5 years. Diabetic retinopathy was found in 15% Euthyroid and 37.5% Hypothyroid diabetics (p=0.002). Neuropathy was more in Hypothyroid (35%) as compared to Euthyroid (12.5%) patients (p=0.003). Prevalence of Nephropathy was also significantly more (p=0.011) in Hypothyroids (60%) as compared to Euthyroid (38.75%).
 Conclusion: Significant association was found between hypothyroidism and micro vascular complications in type 2 Diabetes mellitus. Screening of diabetics for thyroid functions is essential to reduce morbidity.
 Keywords: Diabetes, thyroid, retinopathy, neuropathy, nephropathy
Highlights
Diabetes mellitus (DM) is common metabolic disorder leading to various complications including microvascular complication
Diabetes and thyroid dysfunction can result in abnormalities of one another, as both are strongly implicated in cellular metabolism
Diabetic retinopathy was found in 15% Euthyroid and 37.5% Hypothyroid diabetics (p=0.002)
Summary
Diabetes mellitus (DM) is common metabolic disorder leading to various complications including microvascular complication. Material and Methods: This Hospital based Cross sectional analytical Study was included 80 Euthyroid and 80 hypothyroid patients of type 2 DM. These patients were subjected to fundus examination (for retinopathy), urine for spot albumin and creatinine ratio and routine microscopy (for nephropathy), clinical examination and NCV (for neuropathy). Diabetic Retinopathy is one of the most frequent microvascular complications of DM and is the foremost cause of blindness throughout the world.[3,4] Around 20% 40% of patients having diabetes develop Diabetic Nephropathy.[5] Diabetic nephropathy is the foremost reason of End Stage Renal Disease and a leading reason of DM associated morbidity and mortality. Diabetic Neuropathy occurring in around 50% of individuals with DM can manifest as poly/mono and/or automatic neuropathy.[6]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Medical and Biomedical Studies
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
