Abstract

Studies investigating the possible role of hyperhomocysteinemia (HHC) in increasing postoperative morbidity and mortality among postmenopausal women undergoing on-pump primary isolated coronary artery bypass grafting (CABG) surgery are sparse in the literature. The knowledge about the relationship of preoperative HHC and postoperative adverse cardiovascular events is not adequately covered. This study is initiated to ascertain the hypothesized higher prevalence of HHC in postmenopausal women with ischemic heart disease (IHD) scheduled for on-pump primary isolated CABG and tracing its association to the proposed adverse postoperative complications especially thromboembolic ones linked in the literature to HHC.

Highlights

  • Homocysteine (HCY) is a sulfur-containing amino acid derived from methionine

  • Whereas 30-50% of the variation in cardiovascular disease occurrence remains unexplained by the known traditional risk factors such as smoking, hypercholesterolemia, hypertension, and diabetes mellitus [3,4], experimental and epidemiological based-evidence suggests that HHC is an independent risk factor for the development of atherosclerosis, thrombosis, and other cardiovascular diseases, which may be attributed to impaired fibrinolysis or increased platelet reactivity [5,6,7]

  • The study population was divided into two groups based on their HCY level

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Summary

Introduction

Homocysteine (HCY) is a sulfur-containing amino acid derived from methionine. Its metabolism involves remethylation, transsulfuration, and demethylation processes, which require folic acid, vitamin B12, and vitamin B6 [1]. It increases significantly in women, approaching those in men This is most probably due to estrogen deficiency because in young woman where estrogen production is high, serum lipids and HCY levels are normal [10]. Studies investigating the possible role of hyperhomocysteinemia (HHC) in increasing postoperative morbidity and mortality among postmenopausal women undergoing on-pump primary isolated coronary artery bypass grafting (CABG) surgery are sparse in the literature. This study is initiated to ascertain the hypothesized higher prevalence of HHC in postmenopausal women with ischemic heart disease (IHD) scheduled for onpump primary isolated CABG and tracing its association to the proposed adverse postoperative complications especially thromboembolic ones linked in the literature to HHC

Methods
Results
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Conclusion

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