Abstract
Association of FAS Gene Polymorphism(-1378G>A) with Risk of Breast Cancer in Northwestern Iran
Highlights
Breast-cancer is the most common cancer among women
Decreased expression of FAS gene and de-regulation of proapoptotic signaling have been seen in various tumors such as breast-tumors
Single-nucleotide polymorphisms in the promoter of FAS gene such as G>A substitution at nucleotide position -1378 that is located within the Sp1 transcription-factor binding site, may influence FAS expression
Summary
Breast-cancer is the most common cancer among women. FAS gene is crucial and important in the apoptotic pathway of cell death. استعداد ابتلاء به سرطان پستان مورد بررسی قرار گرفته است. مواد و روش ها :این مطالعه بر روی 831بیمار مبتلاء به سرطان پستان و 851نفر سالم(کنترل) انجام شد .ژنوتایپ های مختلف پلی مورفیسم FAS-1378G>Aبا استفاده از واکنش زنجیره ای پلی مراز تترا آرمز( )Tetra-ARMS-PCRو توالی یابی مستقیم
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