Abstract
THE African form of Burkitt lymphoma (BL) is consistently associated with Epstein–Barr virus (EBV), as judged from the presence of elevated serum titres against viral antigens, and the occurrence of EBV DNA and EBV-associated nuclear antigen (EBNA) in the tumour cells1,2. It has been postulated that EBV has a role in the causation of BL in Africa. It has also been suggested that aetiological cofactors contribute to the high tumour incidence in the endemic areas. In particular malaria has been proposed by Burkitt3 because of the geographical coincidence of BL and holo- or hyperendemic malaria. Rare cases of BL occur outside Africa but have not been shown to be associated with EBV4. We now present evidence for such an association.
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