Abstract
Association of Complex Fractionated Electrograms with Atrial Myocardial Thickness and Fibrosis
Highlights
Radiofrequency ablation has been an important treatment strategy for persistent atrial fibrillation (AF), it is remains challenging and results are unsatisfactory.[1]
The atrial myocardium was significantly thicker at complex fractionated atrial electrograms (CFAE) sites (1757.5±560.5 μm) than at non-CFAE sites (1279.5±337.2 μm) (p=0.036)
Relationship Between Thickness and Amount of Fibrosis in the Atrial Myocardium According to the CFAE
Summary
Radiofrequency ablation has been an important treatment strategy for persistent atrial fibrillation (AF), it is remains challenging and results are unsatisfactory.[1]. Since negative results of CFAE ablation have been reported, characteristics of CFAE sites as an electrophysiological substrate should be more accurately identified and reflected in clinical practice.[4,5] we sought to evaluate the structural differences between CFAE and non-CFAE sites by comparing their histopathologic features. We investigated structural differences between CFAE sites and their matched non-CFAE sites by comparing their histopathologic characteristics in canine AF models. Conclusion: This study provides a better understanding of histological characteristics of CFAE sites, namely a thicker wall and greater amount of fibrosis. These findings may be associated with the development of CFAE and its pathophysiological contribution to AF
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