Abstract
Aims Omentin-1, a newly identified adipokine, has been demonstrated to be associated with bone metabolism, but the results have been inconsistent. Moreover, the potential relationship of circulating omentin-1 with diabetic osteoporosis has never been reported. This study is intended for studying the association between circulating omentin-1, bone mineral density (BMD), prior fragility fractures, and other bone metabolic-related parameters. Methods Circulating omentin-1 levels were measured in 172 patients with type 2 diabetes mellitus (T2DM), and participants were divided into the normal BMD group (n = 52), the osteopenia group (n = 66), and the osteoporosis group (n = 54). The relationship between circulating omentin-1 and diabetic osteoporosis and other parameters was analyzed. Results Circulating omentin-1 was significantly higher in the osteoporosis group than in the normal group and in the osteopenia group (both P < 0.05). Circulating omentin-1 levels were correlated significantly and positively with sex; high-density lipoprotein cholesterol; apolipoprotein A; and prevalence of prior fragility fractures, diabetic nephropathy, and retinopathy; they were correlated negatively with diastolic blood pressure, triglyceride, hemoglobin, atherogenic index of plasma, osteoporosis self-assessment tool for Asians, BMD at different skeletal sites, and corresponding T scores, irrespective of age, sex, and body mass index (P < 0.01 or P < 0.05). Moreover, circulating omentin-1 was an independent decisive factor for the presence of osteoporosis only in women after multivariate adjustment (odds ratio: 1.069; 95% confidence interval: 1.003-1.139; P < 0.05). Lastly, the analysis of receiver operating characteristic curves revealed that the best cutoff value for circulating omentin-1 to predict diabetic osteoporosis was 15.37 ng/mL (sensitivity: 71.7%; specificity: 58.5%) in female subjects. Conclusions High levels of circulating omentin-1 may be associated with the development of osteoporosis in female diabetic subjects and may be a potential biomarker for diabetic osteoporosis in women.
Highlights
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by an elevated level of blood glucose and insulin resistance (IR), leading to microvascular disease and macrovascular complications
This is the first study to explore the relationship between circulating omentin-1 and the risk of osteoporosis in T2DM patients
We found that circulating omentin-1 in the osteoporosis group was significantly increased compared to those in the normal and osteopenia groups
Summary
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by an elevated level of blood glucose and insulin resistance (IR), leading to microvascular disease and macrovascular complications. Recent studies have revealed that osteoporosis, a common diabetic-related complication, is rapidly on the rise, affecting nearly 75 million people worldwide and causing more than 2 million fractures annually [1]. Diabetic osteoporosis has emerged as a serious global burden upon human health and economic development. There are few effective therapies for diabetic osteoporosis. It is an urgent task to seek clinically suitable surrogate markers of osteoporosis for preventing and treating diabetic osteoporosis at an early stage
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