Abstract
Association of Brain-derived Neurotrophic Factor (BDNF) Gene SNPs G196A and C270T with Parkinson’s disease: A Meta- Analysis
Highlights
Brain-derived neurotrophic factor (BDNF) plays a key role in promoting the survival of neurons in the nervous system
Results of present meta-analysis identified an association between recessive AA Vs GG+AG genotype and Parkinson’s Disease (PD) in Asian population but no association between BDNF 196 G/A polymorphism and PD in European population
Our meta-analysis demonstrate that the evidence for associations between BDNF polymorphisms (G196A and C270T) and PD risk for few allele and genotype combinations are present but is ethnicity dependent
Summary
Brain-derived neurotrophic factor (BDNF) plays a key role in promoting the survival of neurons in the nervous system. Parkinson’s disease (PD) is the most common neurodegenerative disorder, clinically characterized by resting tremor, rigidity, gait abnormalities, postural imbalance and bradykinesia [1] These underlying pathological events in PD result from the death of dopamine-generating cells in the region of the midbrain [2]. The brain-derived neurotrophic factor (BDNF) gene, encoding a nerve growth factor, and promoting the survival of dopaminergic neurons in the substantia nigra, is highly expressed in the nervous system [7,8]. Decreased BDNF mRNA expression and protein have been observed in the substantia nigra of PD patients [9,10] making BDNF, an important candidate gene for PD risk Based on these observations, several molecular epidemiological studies have investigated the association of BDNF
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