Abstract
IntroductionLung cancer is considered one of the most common and lethal types of cancer. Risk factors include smoking, genetic susceptibility and chronic obstructive pulmonary disease (COPD). Autophagy, a mechanism to recycle damaged organelles and proteins that can cause also cell death by an alternative way to apoptosis, could be involved in lung cancer development. MethodsWe have studied the genotype distribution for ATG2B (rs3759601), ATG5 (rs2245214), ATG10 (rs1864183) and ATG16L1 (rs2241880) polymorphisms in a sample of Spanish cohort of subjects with lung cancer compared to healthy volunteers. We also investigated the possible association of these polymorphisms in patients of lung cancer with and without COPD. ResultsPatients with lung cancer exhibited a difference in allele distribution in ATG16L1 (rs2241880) polymorphism compared to the control group. The GG genotype showed a protective role in patients without COPD. Distribution of alleles in the other three polymorphisms was not statistically different between groups. ConclusionsATG16L1 is closely related to apoptosis and immunity, and a decrease in its effect may favor cell death over inflammation and autophagy. This could explain the protective role of ATG16L1 (rs2241880) in our sample of smokers especially without COPD. Further confirmation is still required in other series.
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