Abstract
Angiopoietin-like protein 8 (ANGPTL8) has a role in lipid metabolism, beta-cell proliferation and diabetes progression, however, the association between different variants in the ANGPTL8 gene and metabolic syndrome (MetS) components has not been studied widely especially in Arab ethnic groups. In this study, the associations of ANGPTL8 variants on MetS risk in Saudi Arab adults were investigated. A total of 905 unrelated Saudi adults (580 healthy controls and 325 MetS) were included. MetS was screened based on the International Diabetes Federation (IDF) criteria. The genotype and allele frequency distribution of rs737337 (T/C) and rs2278426 (C/T) polymorphism in ANGPTL8 gene was studied. Participants with MetS were significantly older, had higher BMI, and rs737337 polymorphism frequency was significantly lower than in control. Furthermore, the TC + CC genotype and C allele of rs737337 (T/C) was associated with decreased risk of hypercholesterolemia and hyperglycemia [odds ratio (OR) 0.61, 95%CI 0.40–0.93, p = 0.016 and OR 0.58, 0.39–0.86, p = 0.007 respectively for hypercholesterolemia; and OR 0.66, 0.45–0.97, p = 0.032 and OR 0.65, 0.46–0.93; p = 0.016 respectively for hyperglycemia]. Similarly, CT, CT + TT genotype and T allele of rs2278426 (C/T) were associated with decreased risk of hyperglycemia (p < 0.05). In conclusion, the study suggests that the gene variants in SNPs rs 737337 (T/C) and rs 2278426 (C/T) are associated with lower risk of hypercholesterolemia and hyperglycemia. These findings supplement the growing literature supporting the role of ANGPTL8 in lipid and glucose metabolism.
Highlights
Metabolic syndrome is a low-grade inflammation and oxidative stress state represented by a cluster of disorders including abdominal obesity, dyslipidemia, hypertension and insulin resistance[1]
Angiopoietin-like protein 8 (ANGPTL8) is known to play a key role in lipid metabolism[22], and our study showed that ANGPTL8 gene variants were significantly associated with total cholesterol and TG levels
The study investigated the gene variants in SNPs rs 737337 (T/C) and rs 2278426 (C/T) in association with the risk of metabolic syndrome (MetS) and its individual components in Saudi adults and found that these variants are associated with lower risk of hypercholesterolemia and hyperglycemia as components of MetS
Summary
Metabolic syndrome is a low-grade inflammation and oxidative stress state represented by a cluster of disorders including abdominal obesity, dyslipidemia, hypertension and insulin resistance[1] This condition predisposes itself to vascular harm and subsequent manifestation of complications like cardiovascular diseases, type 2 diabetes mellitus (T2DM)[2]. Angiopoietin-like protein 8 (ANGPTL8) or betatrophin, first identified in 2012, is a novel member of a group of secretory glycoproteins due to its role in lipid metabolism[4]. It is expressed abundantly in human liver, whereas in mice, its expression was shown to be high in liver, white and brown adipose tissues[5]. The third SNP rs145464906 (CAG to TAG) results in a premature stop codon at residue 12118
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
