Abstract
Objective To analyze the association between uric acid levels and bone mineral density in postmenopausal women with type 2 diabetes mellitus. Methods We retrospectively analyzed 262 postmenopausal women with type 2 diabetes mellitus, to assess uric acid levels and bone mineral density using the T score of dual-energy X-ray absorptiometry. Results (1) Women in the osteoporosis group demonstrated higher uric acid levels and lower estimated glomerular filtration rate (p < 0.05, respectively). (2) Uric acid levels were positively correlated with the hip and lumbar spine bone mineral density and T score (r = 0.17, p < 0.05; r = 0.25, p < 0.05; r = 0.17, p < 0.05; and r = 0.28, p < 0.05, respectively). Meanwhile, there was a positive relation between estimated glomerular filtration rate and hip bone mineral density (r = 0.22, p < 0.05). (3) Logistic regression analysis showed that age, body mass index, and diabetic duration are independent risk factors for osteoporosis in postmenopausal women with type 2 diabetes mellitus. The level of estimated glomerular filtration rate and uric acid levels were not independent effect factors for osteoporosis in menopausal women. Conclusion Uric acid levels are neither a protective factor nor a risk factor for osteoporosis in women with type 2 diabetes mellitus.
Highlights
With continuously changing modern lifestyle and increase in the number of aging individuals, comorbidities such as type 2 diabetes mellitus (T2DM) and osteoporosis (OP), which gradually increase in incidence with age, have become common health problems [1, 2]
A large number of studies have shown that uric acid (UA) has certain protective effects on a variety of diseases caused by high oxidative stress, including osteoporosis [7], so it is generally considered that UA is a protective factor of osteoporosis
Hyperuricemia can aggravate the progress of diabetes; hyperglycemia can lead to bone fragility [8], so hyperuricemia can indirectly accelerate bone loss in T2DM patients
Summary
To analyze the association between uric acid levels and bone mineral density in postmenopausal women with type 2 diabetes mellitus. We retrospectively analyzed 262 postmenopausal women with type 2 diabetes mellitus, to assess uric acid levels and bone mineral density using the T score of dual-energy X-ray absorptiometry. (1) Women in the osteoporosis group demonstrated higher uric acid levels and lower estimated glomerular filtration rate (p < 0:05, respectively). There was a positive relation between estimated glomerular filtration rate and hip bone mineral density (r = 0:22, p < 0:05). The level of estimated glomerular filtration rate and uric acid levels were not independent effect factors for osteoporosis in menopausal women. Uric acid levels are neither a protective factor nor a risk factor for osteoporosis in women with type 2 diabetes mellitus
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