Abstract
BackgroundThyroid hormones are known to have direct and indirect effects on metabolism. Individuals with metabolic syndrome, a disease that is growing in incidence at a rapid rate, are at higher risk for cardiovascular disease, diabetes, and cancer. The aim of this study was to identify whether significant correlations exist between thyroid hormone levels and components of the metabolic syndrome in the general population of Korea.MethodsThe data were collected from the sixth Korea National Health and Nutrition Examination Surveys from 2013 to 2015. A total of 1423 participants were tested for thyroid function. The analysis of variance and multiple linear regression were performed to analyze the relationship between thyroid hormone level and components of the metabolic syndrome.ResultsA positive association between free thyroxine and fasting glucose level was observed in patients with high free thyroxine levels (≥1.70 ng/dL, β = 15.992, p = < 0.0001), when compared with patients with normal-middle free thyroxine levels. Moreover, a negative association was observed between free thyroxine and triglyceride levels in patients with normal-high free thyroxine levels (β = − 21.145, p = 0.0054) and those with high free thyroxine levels (β = − 49.713, p = 0.0404).ConclusionFree thyroxine shows a partially positive association with fasting glucose and a partially negative association with triglycerides in the Korean population. In patients with abnormal thyroid function, follow up tests for glucose levels and lipid profiling during treatment for thyroid dysfunction would be beneficial in terms of overlooking metabolic syndrome and to prevent related diseases.
Highlights
Thyroid hormones are known to have direct and indirect effects on metabolism
After controlling for covariates, the results showed a positive association between Free thyroxine (FT4) and fasting glucose level in patients with high FT4 levels when compared to those with normal-middle FT4 levels (β = 15.992; p = < 0.0001)
Glucose level and lipid profile are metabolic syndrome components; metabolic syndrome is strongly correlated with diseases such as diabetes and cardiovascular disease that are associated with high mortality and morbidity rates
Summary
Thyroid hormones are known to have direct and indirect effects on metabolism. Individuals with metabolic syndrome, a disease that is growing in incidence at a rapid rate, are at higher risk for cardiovascular disease, diabetes, and cancer. Lambadiari et al reported that thyroid hormones are significant determinants of glucose homeostasis [9], and affect fasting glucose levels by antagonizing insulin action [9]. Klein et al reviewed several studies regarding the mechanism of action of thyroid hormones on the cardiovascular system [11]. Especially hyperthyroidism, often demonstrated signs and symptoms of cardiovascular changes [11]. Most of the studies that assessed the relationships between abnormal thyroid hormone levels and metabolic syndrome have been conducted in Caucasian populations [2, 13]. The aim of this study was to assess the relationships between thyroid hormone levels and metabolic syndrome components in a nationally representative sample of South Korean adults
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