Abstract
BackgroundThe present study aimed to expound the association between the XK related 6 gene (XKR6) rs7819412 single nucleotide polymorphism (SNP) and serum lipid profiles and the risk of coronary artery disease (CAD) and ischemic stroke.MethodsThe genetic makeup of the XKR6 rs7819412 SNP in 1783 unrelated participants (controls, 643; CAD, 588 and ischemic stroke, 552) of Han Chinese was obtained by the Snapshot technology.ResultsThe genotypic frequencies of the SNP were disparate between CAD (GG, 81.0%; GA/AA, 19.0%) or ischemic stroke (GG, 81.2%; GA/AA, 18.8%) patients and healthy controls (GG, 85.7%, GA/AA, 14.3%; P < 0.05 vs. CAD or ischemic stroke; respectively). The A allele frequency was also diverse between CAD (10.1%) or ischemic stroke (10.0%) and control groups (7.5%; P < 0.05 vs. CAD or ischemic stroke; respectively). The GA/AA genotypes and A allele were associated with high risk of CAD and ischemic stroke (CAD: P = 0.026 for GA/AA vs. GG, P = 0.024 for A vs. G; Ischemic stroke: P = 0.029 for GA/AA vs. GG, P = 0.036 for A vs. G). The GA/AA genotypes were also associated with increased serum triglyceride (TG) concentration in CAD and total cholesterol (TC) concentration in ischemic stroke patients.ConclusionsThese data revealed that the XKR6 rs7819412 A allele was related to increased serum TG levels in CAD, TC levels in ischemic stroke patients and high risk of CAD and ischemic stroke.
Highlights
The present study aimed to expound the association between the XK related 6 gene (XKR6) rs7819412 single nucleotide polymorphism (SNP) and serum lipid profiles and the risk of coronary artery disease (CAD) and ischemic stroke
The height, weight, body mass index (BMI), systolic blood pressure, glucose, pulse pressure, serum low-density lipoprotein cholesterol (LDL-C), TG and total cholesterol (TC) levels were significantly lower; and serum high-density lipoprotein cholesterol (HDL-C) and ApoA1 levels, the ApoA1/ ApoB ratio, and the proportion of drinkers were significantly higher in controls than in CAD and ischemic stroke patients
The current study showed that the allelic and genotypic frequencies of the rs7819412 SNP were markedly different between controls and patients with ischemic stroke or CAD, and the A allele and GA/AA genotypes were associated with an increased risk of ischemic stroke and CAD in the Han Chinese
Summary
The present study aimed to expound the association between the XK related 6 gene (XKR6) rs7819412 single nucleotide polymorphism (SNP) and serum lipid profiles and the risk of coronary artery disease (CAD) and ischemic stroke. Previous studies have shown that CAD occurs due to various factors and can be subjective to genomic background, lifestyle, environmental factors and alterations of plasma lipid levels as well as their interactions with each other [4, 5]. The association between the XKR6 rs7819412 SNP and blood lipid levels and the risk of CAD and ischemic stroke is not clear and not reported in the Han Chinese. This study was designed to understand the relationship between the XKR6 rs7819412 SNP and several serum lipid parameters and the risk of CAD and ischemic stroke in the Han Chinese
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