Abstract
Associations between the NQO1 C609T polymorphism and hepatocellular carcinoma (HCC) risk are a subject of debate. We therefore performed the present meta-analysis to evaluate links with HCC susceptibility. Several major databases (PubMed, EBSCO), the Chinese national knowledge infrastructure (CNKI) and the Wanfang database were searched for eligible studies. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to measure the strength of associations. A total of 4 studies including 1,325 patients and 1,367 controls were identified. There was a significant association between NQO1 C609T polymorphism and HCC for all genetic models (allelic model: OR=1.45, 95%CI=1.23-1.72, p<0.01; additive model: OR=1.96, 95%CI=1.57-2.43, p<0.01; dominant model: OR=1.62, 95%CI=1.38-1.91, p<0.01; and recessive model: OR=1.53, 95%CI=1.26-1.84, p<0.01). On subgroup analysis, similarly results were identified in Asians. For Asians, the combined ORs and 95% CIs were (allelic model: OR=1.50, 95%CI=1.24-1.82, p<0.01; additive model: OR=2.11, 95%CI=1.48-3.01, p<0.01; dominant model: OR=1.69, 95%CI=1.42-2.02, p<0.01; and recessive model: OR=1.59, 95%CI=1.16-2.19, p<0.01). The current meta-analysis suggested that the NQO1 C609T polymorphism could be a risk factor for developing HCC, particularly in the Chinese population.
Highlights
Hepatocellular carcinoma (HCC) is the fifth most common cause of cancer and the third leading cause of cancer-related death worldwide (El-Serag and Rudolph, 2007; de Lope et al, 2012)
In the stratified analyses by ethnicity (Asian or Caucasian), we found that the NQO1 C609T polymorphism significantly increased the risk of HCC in Asian populations in the all genetic models (Table 2)
There were a number of studies performed to detect the association between NQO1 C609T polymorphism and HCC, but no consistent results were reported, this was largely attributed to the small samples or the relatively low statistical power of published studies
Summary
Hepatocellular carcinoma (HCC) is the fifth most common cause of cancer and the third leading cause of cancer-related death worldwide (El-Serag and Rudolph, 2007; de Lope et al, 2012). Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection is common environmental factors cause HCC. Some single nucleotide polymorphisms (SNPs) have been regarded as HCC risk factors (Kato et al, 2005; Kim and Lee, 2005; Liu et al, 2013). Associations between the NQO1 C609T polymorphism and hepatocellular carcinoma (HCC) risk are a subject of debate. There was a significant association between NQO1 C609T polymorphism and HCC for all genetic models (allelic model: OR=1.45, 95%CI=1.23-1.72, p
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