Abstract
Background: Many studies have been performed to explore the combined effects of glutathione-S-transferase M1 (GSTM1) present/null and cytochrome P4501A1 (CYP1A1) MspI polymorphisms with lung cancer (LC) risk, but the results are contradictory. Two previous meta-analyses have been reported on the issue in 2011 and 2014. However, several new articles since then have been published. In addition, their meta-analyses did not valuate the credibility of significantly positive results.Objectives: We performed an updated meta-analysis to solve the controversy following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.Methods: False-positive report probability (FPRP), Bayesian false discovery probability (BFDP), and the Venice criteria were used to verify the credibility of meta-analyses.Results: Twenty-three publications including 5734 LC cases and 7066 controls met the inclusion criteria in the present study. A significantly increased risk of LC was found in overall analysis, Asians and Indians. However, all positive results were considered as ‘less-credible’ when we used the Venice criteria, FPRP, and BFDP test to assess the credibility of the positive results.Conclusion: These positive findings should be interpreted with caution and results indicate that significant associations may be less-credible, there are no significantly increased LC risk between the combined effects of GSTM1 present/null and CYP1A1 MspI polymorphisms.
Highlights
Many studies have been performed to explore the combined effects of glutathione-S-transferase M1 (GSTM1) present/null and cytochrome P4501A1 (CYP1A1) MspI polymorphisms with lung cancer (LC) risk, but the results are contradictory
An updated meta-analysis was calculated to investigate the association between the combined effects of GSTM1 present/null and CYP1A1 MspI polymorphisms with LC risk
We observed that the individuals carrying GSTM1 null/CYP1A1 m1/m1, GSTM1 present/CYP1A1 m1/m2, GSTM1 null/CYP1A1 m1/m2, GSTM1 null/CYP1A1 m2/m2, GSTM1 present/CYP1A1 m*, GSTM1 null/CYP1A1 m*, and all risk genotypes were associated with LC risk
Summary
Many studies have been performed to explore the combined effects of glutathione-S-transferase M1 (GSTM1) present/null and cytochrome P4501A1 (CYP1A1) MspI polymorphisms with lung cancer (LC) risk, but the results are contradictory. Several new articles since have been published Their meta-analyses did not valuate the credibility of significantly positive results. Conclusion: These positive findings should be interpreted with caution and results indicate that significant associations may be less-credible, there are no significantly increased LC risk between the combined effects of GSTM1 present/null and CYP1A1 MspI polymorphisms. Lung cancer (LC) is one of the most common malignancies and it is the leading cause of cancer deaths in both men and women [1–3] It is an extremely complex disease because it is the result of the combined effects of genes, environment, and lifestyle [4–6]. As the preservation of genomic integrity is essential in the prevention of License 4.0 (CC BY)
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