Abstract
BackgroundRecent studies have shown osteocalcin (OC) plays an important role in regulating glucose and lipid metabolism. Thus, the aim of this study was to investigate the association of OC with glucose and lipid metabolism in patients with type 2 diabetes mellitus (T2DM) in the Chinese Han and Uygur population.MethodsA total of 1397 T2DM patients (705 Han and 692 Uygur T2DM patients) were enrolled in the present study. Lipid profile, glucose metabolic indices and total OC (TOC) were measured. Homeostasis model assessment of β-cells function (HOMA-β), insulin sensitivity (HOMA-IS) and insulin resistance (HOMA-IR) were also calculated in all participants. Pearson/Spearman correlation analysis and multivariate stepwise regression analysis were adopted to test the relationships between OC and those parameters.ResultsUygur T2DM patients had significantly higher body mass index (BMI), hemoglobin A1C (HbA1C) and lower TOC compared with their Han counterparts (all P < 0.05). HbA1C was negatively associated with TOC in all Uygur and Han T2DM patients (Total: Uygur: t = −3.468, P = 0.001; Han: t = −4.169, P < 0.001). BMI was inversely associated with TOC in all Uygur T2DM patients (Males: t = −2.893, P = 0.014; Females: t = −2.250, P = 0.027, respectively). Multivariate stepwise regression analysis showed that TOC was positively correlated with HOMA-β in the Uygur male group (β = 2.101, P = 0.040) and negatively associated with BMI in all Uygur T2DM patients (Males: β = −1.563, P = 0.011; Females: β = −1.284, P = 0.016, respectively). No significant differences were observed between TOC and lipid profiles in all participants (all P > 0.05).ConclusionThere were differences in the associations between TOC and glucose metabolism in Han and Uygur T2DM patients, indicating genetic factors may play a role in modulating OC and glucose metabolism in different ethnic population.
Highlights
Recent studies have shown osteocalcin (OC) plays an important role in regulating glucose and lipid metabolism
There were no differences between HbA1C in all participants (Han) and Uygur type 2 diabetes mellitus (T2DM) patients with respect to age, course of disease, systolic blood pressure (SBP), diastolic blood pressure (DBP), Bone mass density (BMD)-neck, BMD-greater trochanter (GT), BMD (L1–4), previous medications and prevalence of comorbidities
Males and females, Uygur T2DM patients had higher Waist circumference (WC), body mass index (BMI) and higher prevalence of obesity compared with their Han counterparts
Summary
Recent studies have shown osteocalcin (OC) plays an important role in regulating glucose and lipid metabolism. The aim of this study was to investigate the association of OC with glucose and lipid metabolism in patients with type 2 diabetes mellitus (T2DM) in the Chinese Han and Uygur population. As an osteoblast-derived hormone, osteocalcin (OC) is an indicator of both osteoblast activity and bone formation. Lee et al showed that OC is a bone messenger affecting both adipocytes and insulin-producing β-cells It increases β-cells proliferation, insulin secretion, insulin sensitivity, adiponectin expression and energy expenditure by upregulating the expression of adiponectin gene in adipocytes [2]. Adiponectin enhances insulin sensitivity, indicating there is an interaction among bone, adiposederived factors and glucose/lipid metabolism
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