Abstract
Purpose: In most cases, by the time clinical or radiographic evidence of osteoarthritis (OA) is established, significant and irreversible disease progression has already occurred, impairing the disease prognosis. Serum levels of cartilage and joint-specific biochemical markers such cartilage oligomeric matrix protein (COMP), matrix metalloproteinase (MMP)-3, and hyaluronan (HA) are associated with cartilage degradation, joint tissue degradation, and synovitis in patients with OA. Change in these OA-related biomarkers may precede the morphological and clinical manifestations of OA and therefore have been explored as predictive markers in OA.
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