Abstract
It is indicated that lipids profiles are associated with carotid plaque and Atherosclerosis. However, studies about the relationship between serum lipid profiles and carotid plaque composition in Chinese Population is limited. We conducted a cross-sectional study among 3,214 participants between January 2015 and December 2017 in China, to investigate the association between various lipid profiles and the prevalence of carotid plaque. Logistic regression model was used to investigate the association between plasma lipid profiles and odds of carotid plaque. Analysis of covariance (ANCOVA) was used to compare the mean plasma lipid profiles among different number and composition of carotid artery plaques. HDL-C, Non-HDL-C levels, TC/HDL-C, LDL-C/HDL-C were significantly associated with the presence of carotid plaque; HDL-C, LDL-C, Non-HDL-C levels, TC/HDL-C, LDL-C/HDL-C were significantly associated with the presence of common carotid artery (CCA) plaque. Compare with participants without carotid plaque, increased level of LDL-C/HDL-C was found in those with echolucent/polytype plaque. Similarly, compared with participants without CCA plaque, increased level of LDL-C/HDL-C was found in those with echolucent plaque. In conclusion, we found that serum HDL-C, Non-HDLc level, TC/HDLc, and LDLc/HDLc were all associated with the prevalence of carotid plaque, and LDL-C/HDL-C differed among different group of carotid plaque composition.
Highlights
It is indicated that lipids profiles are associated with carotid plaque and Atherosclerosis
Previous studies suggested that lipid profiles (i.e. TC, TG, HDL-C, LDL-C) were significantly associated with carotid plaque[10,11,12,13,14]
The main results are as follows: serum HDL-C level was negatively associated with odds of carotid plaque and common carotid artery (CCA) plaque; serum LDL-C level was positively associated with odds of CCA plaque; serum Non-HDLc level, TC/HDLc, and LDLc/HDLc were positively associated with odds of both carotid plaque and CCA plaque
Summary
It is indicated that lipids profiles are associated with carotid plaque and Atherosclerosis. Compared with participants without CCA plaque, increased level of LDL-C/HDL-C was found in those with echolucent plaque. We found that serum HDL-C, Non-HDLc level, TC/HDLc, and LDLc/HDLc were all associated with the prevalence of carotid plaque, and LDL-C/HDL-C differed among different group of carotid plaque composition. Several studies indicated that the presence of plaque predicted the onset of cardiovascular and cerebrovascular diseases more accurately than the mean IMT, and the accuracy of this prediction was equivalent to that from pulse wave velocity in hypertensive patients[6,7,8]. We conducted the current study to investigate the association between various lipid profiles and the prevalence of carotid plaque and carotid plaque composition in a general Chinese population
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