Abstract
Epidemiological studies have demonstrated that interleukin-10 (IL-10) polymorphisms may be associated with the development of Behcet's disease (BD). However, the published results were inconsistent. Therefore, this meta-analysis was conducted to derive a more precise relationship between IL-10 polymorphisms and BD susceptibility. Online databases (PubMed, Embase, Science Citation Index (SCI), CNKI, and WanFang) were searched to identify eligible studies. Odds ratio (OR) and a 95% confidence interval (CI) were applied to assess the relationship strength between IL-10 -1082A>G (rs1800896), -819T>C (rs1800871), and -592A>C (rs1800872) polymorphisms and BD susceptibility. Publication bias, sensitivity, and cumulative analyses were conducted to measure the robustness of our findings. Finally, fifteen articles (36 independent case-control studies) involving 5,971 patients and 8,913 controls were included. Overall, significant associations between -819T>C polymorphisms and BD risk were observed in the total population (C vs. T: OR = 0.72, 95%CI = 0.67‐0.77, P < 0.01, I2 = 36.6%; TC vs. TT: OR = 0.73, 95%CI = 0.66‐0.80, P < 0.01, I2 = 23.0%; CC vs. TT: OR = 0.52, 95%CI = 0.39‐0.70, P < 0.01, I2 = 53.7%; TC+CC vs. TT: OR = 0.67, 95%CI = 0.61‐0.71, P < 0.01, I2 = 22.1%; and CC vs. TT+TC: OR = 0.66, 95%CI = 0.53‐0.82, P < 0.01, I2 = 57.8%). Moreover, the IL-10 -592 A>C polymorphism and the ACC haplotype exhibited a significant, protective effect against BD susceptibility. In summary, our meta-analysis suggested that IL-10 gene polymorphisms may play a salient role for BD development.
Highlights
Behcet’s disease (BD) is a chronic polygenic autoinflammatory disorder, characterized by multiple affected body parts, with common symptoms including recurrent oral ulcers, ocular inflammation, genital ulcers, and skin lesions [1, 2]
Three English databases (PubMed, Embase, and Science Citation Index (SCI)) and two Chinese databases (CNKI and WanFang) were searched with the following terms from their inception up to May 1, 2019: “Interleukin 10,” “IL-10,” “rs1800896,” “rs1800871,” “rs1800872,” “polymorphism,” “variant,” “mutation,” “Behcet’s disease,” and “BD.” Some relevant papers cited within retrieved articles were reviewed through manual searches
Ten publications came from Middle East (ME) [5, 25,26,27,28, 31, 33,34,35,36], five publications came from East Asia (EA) [13, 30, 32, 35], and three publications came from European descendants [25, 29, 37]
Summary
Behcet’s disease (BD) is a chronic polygenic autoinflammatory disorder, characterized by multiple affected body parts, with common symptoms including recurrent oral ulcers, ocular inflammation, genital ulcers, and skin lesions [1, 2]. The most authoritative diagnostic criteria were made according to the criteria of the International Study Group of BD: oral ulceration plus any two genital ulcerations, typical defined eye lesions, typical defined skin lesions, or a positive pathergy test [4]. BD is most common in Asian countries, such as China and Japan (East Asian (EA)), as well as in the Middle East (ME) around the regions of the Old Silk. Road, such as Turkey and Iran [5]. The etiology and pathogenesis of BD have not been elucidated; environmental risks, immunological aberrations, and multiple genetic factors are considered risk factors that can increase susceptibility to BD [10, 11]
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