Abstract
Numerous studies have investigated the association between the polymorphisms or haplotypes in interleukin-18 (IL-18) gene promoter and allergic asthma susceptibility, however, the conclusions were controversial. Thus, we performed this comprehensive meta-analysis to evaluate this correlation. Potentially eligible studies were searched in the common electronic database. A total of nine studies for rs1946518, ten studies for rs187238 as well as four studies for haplotypes of the IL-18 promoter were included. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were implemented to assess the strength of the association between polymorphisms or haplotypes and the risk of asthma. Our meta-analysis revealed that a possible association with asthma susceptibility was identified with borderline significance in the overall analysis under dominant genetic model and heterozygous model for IL-18-607 C/A Polymorphism, under the homozygous genetic model for IL-18-137 G/C polymorphism and haplotype of CC in IL-18 gene promoter. Our meta-analysis indicated that genotype AA and CA in rs1946518 may be a protective role in allergic asthma progress, while carriers of genotype GG in rs187238 may be associated with increased allergic asthma risk. Besides, haplotype of CC in the IL-18 gene promoter may be also associated with allergic asthma susceptibility.
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