Abstract
In the present study, we investigated the association of 12 polymorphisms in six inflammatory-response genes (TNF, IL6, IL10, IL18, NFKB1 and NFKBIA) with risk of acute kidney injury (AKI) in children. The polymorphisms were genotyped in 1138 children with AKI and 1382 non-AKI controls. Logistic regression analysis was performed to calculate the odds ratio for estimating the risk association. After accounting for Bonferroni correction and adjustment for potential confounders, significant association was observed for NFKB1 rs28362491, NFKBIA rs2233406 and NFKBIA rs696 polymorphisms (P < 0.004). All three polymorphisms were associated with a reduced risk of AKI. For rs28362491 polymorphism, the OR for ID vs. II comparison was 0.75 (95% CI = 0.58–0.83) while that for DD vs. II was 0.44 (95% CI = 0.30–0.67). For rs2233406 polymorphism, the CT vs. CC comparison showed an OR of 0.90 (95% CI = 0.39–0.99), while the TT vs. CC comparison showed an OR of 0.43 (95% CI = 0.33–0.80). For rs696 polymorphism, the OR for AG vs. AA comparison was 0.71 (95% CI = 0.43–0.89), while the GG vs. AA comparison showed an OR of 0.39 (95% CI = 0.21–0.71). In conclusion, NFKB1 rs28362491, NFKBIA rs2233406 and NFKBIA rs696 polymorphisms may serve as biomarkers for predicting risk of AKI in children.
Highlights
Acute kidney injury (AKI) is a significant concern in intensive care units, as it is associated with a substantial burden of morbidity, mortality and expenditures in the healthcare sector [1]
We aimed to examine the association of IL6 rs1800795, IL6 rs1800796, IL6 rs1800797, IL10 rs1800896, IL10 rs3021097, NFKB1 rs28362491, NFKBIA rs2233406, NFKBIA rs696, IL18 rs1946518, IL18 rs187238, TNF rs1799964 and TNF rs1800629 polymorphisms with AKI risk among the pediatric population in China
Controls were children who had clinical risk factors for AKI and acute lung injury (ALI) but did not eventually develop the condition. (Note: Risk factors for ALI were included because the present work was part of a larger study which investigates genetic susceptibility to ALI.) Peripheral blood specimens from 1138 cases and 1382 controls were retrieved
Summary
Acute kidney injury (AKI) is a significant concern in intensive care units, as it is associated with a substantial burden of morbidity, mortality and expenditures in the healthcare sector [1]. AKI is characterized by a sudden and unexpected decline in renal function that occurs rapidly, usually as a complication of other medical conditions or procedures, such as septic shock, cardiac surgery and liver transplantation. The reason why only some of the patients with these medical conditions develop AKI remains incompletely explained. Several clinical risk factors of AKI have been identified, including aortic arteriosclerosis, advancing age, hypertension and diabetes mellitus [2]. These risk factors are normally not applicable to the pediatric patients. There is a need for identification of additional factors that can be reliably used to predict whether an individual, especially a child, would develop the syndrome
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