Abstract
Interleukins (ILs) are the most typical inflammatory and immunoregulatory cytokines. Evidences have shown that polymorphisms in ILs are associated with cerebral infarction risk. However, the results remain inconclusive. The present study was to evaluate the role of ILs polymorphisms in cerebral infarction susceptibility. Relevant case-control studies published between January 2000 and December 2015 were searched and retrieved from the electronic databases of Web of Science, PubMed, Embase and the Chinese Biomedical Database. The odds ratio (OR) with its 95% confidence interval (CI) were employed to calculate the strength of association. A total of 55 articles including 12619 cerebral infarction patients and 14436 controls were screened out. Four ILs (IL-1, IL-6, IL-10 and IL-18) contained nine single nucleotide polymorphisms (SNPs; IL-1α −899C/T, IL-1β −511C/T and IL-1β +3953C/T; IL-6 −174G/C and −572C/G; IL-10 −819C/T and −1082A/G; IL-18 −607C/A and −137G/C). Our result showed that IL-1α −899C/T and IL-18 −607C/A (under all the genetic models), and IL-6 −572C/G (under the allelic model, heterogeneity model and dominant model) were associated with increased the risk of cerebral infarction (P<0.05). Subgroup analysis by ethnicity showed that IL-6 −174G/C polymorphism (under all the five models) and IL-10 −1082A/G polymorphism (under the allelic model and heterologous model) were significantly associated with increased the cerebral infarction risk in Asians. Other genetic polymorphisms were not related with cerebral infarction susceptibility under any genetic models. In conclusion, IL-1α −899C/T, IL-6 −572C/G and IL-18 −607C/A might be risk factors for cerebral infarction development. Further studies with well-designed and large sample size are still required.
Highlights
Cerebral infarction, resulting from a blockage in the blood vessels supplying blood to the brain, or leakage outside the vessel walls, is the leading cause of acquired disability in adults and the second leading cause of dementia [1]
Our result found that the frequency of A allele was a little higher in controls than that in patients (55.0% versus 48.1%), but the A allele of IL-18 − 607C/A polymorphism was associated with increased the risk of cerebral infarction (A versus C: odds ratio (OR) = 0.76, 95% confidence interval (CI) = 0.69–0.84, P < 0.00001)
Our result found that IL-18 − 137G/C polymorphism was not associated with cerebral infarction risk under any genetic comparison models (Table 3)
Summary
Cerebral infarction (or ischaemic stroke), resulting from a blockage in the blood vessels supplying blood to the brain, or leakage outside the vessel walls, is the leading cause of acquired disability in adults and the second leading cause of dementia [1]. It constitutes the majority of cases of cerebrovascular accidents, and can be atherothrombotic or embolic [2]. The symptoms of cerebral infarction are determined by the parts of the brain affected, and the pathology and pathophysiology of this disease are still not well understood [9].
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