Abstract
AimTo investigate the association between different family history risk categories and prevalence of diabetes in the Chinese population.MethodsThe family history of diabetes was obtained from each subject, and an oral glucose tolerance test was performed for measuring the fasting and postload glucose and insulin levels based on a national representative cross-sectional survey of 46,239 individuals (age ≥ 20 years) in the 2007–2008 China National Diabetes and Metabolism Disorders Study. The family history risk categories of diabetes were high, moderate, and average (FH2 and FH1: at least two generations and one generation of first-degree relatives with diabetes, respectively; FH0: no first-degree relatives with diabetes).ResultsThe age- and gender-adjusted prevalence rates of diabetes were 32.7% (95% confidence interval (CI): 26.4–39.7%) in FH2, 20.1% (95% CI: 18.2–22.1%) in FH1, and 8.4% (95% CI: 7.9–8.9%) in FH0 (P < 0.0001). The calculated homeostatic model assessment-estimated insulin resistance (HOMA-IR), Matsuda insulin sensitivity index (ISI), and insulinogenic index (ΔI30/ΔG30) values showed significant trending changes among the three risk categories, with the most negative effects in FH2. Multivariate logistic regression analysis showed that the odds ratios of having diabetes were 6.16 (95% CI: 4.46–8.50) and 2.86 (95% CI: 2.41–3.39) times higher in FH2 and FH1, respectively, than in FH0 after adjustment for classical risk factors for diabetes.ConclusionsFamily history risk categories of diabetes have a significant, independent, and graded association with the prevalence of this disease in the Chinese population.
Highlights
Diabetes mellitus is a major noncontagious disease that has become a serious threat to human health
The family history of diabetes was obtained from each subject, and an oral glucose tolerance test was performed for measuring the fasting and postload glucose and insulin levels based on a national representative cross-sectional survey of 46,239 individuals in the 2007–2008 China National Diabetes and Metabolism Disorders Study
The age- and gender-adjusted prevalence rates of diabetes were 32.7% (95% confidence interval (CI): 26.4–39.7%) in FH2, 20.1% in FH1, and 8.4% in FH0 (P < 0.0001)
Summary
Diabetes mellitus is a major noncontagious disease that has become a serious threat to human health. According to the latest estimates of the International Diabetes Federation, the prevalence of diabetes worldwide has reached 8.3%, and approximately 382 million adults have had diabetes, and 80% of these adults are present in medium and low income countries with scarce health resources [1]. If the American Diabetes Association standard (glycated hemoglobin 6.5%) is included in the diagnostic criteria for diabetes, the prevalence of diabetes in the Chinese population reaches 11.6% [3]. The population size of Chinese patients with diabetes is estimated to be 92.4–98.4 million [1,2]; of which, approximately 60% patients have not yet been diagnosed [2]. Due to the scarcity and uneven distribution of health resources in China, effective and targeted screening of high-risk groups and early treatment of diabetes are significant factors for preventing the late complications of this disease
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